CXXC4 Rabbit Polyclonal Antibody from Bioassay Technology Laboratory

This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled: a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition: the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides: localize to promoters and CpG islands: and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2: an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans: a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants